Research Associate, Molecular Medicine

Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built - nor could it be maintained - without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.

When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of Healthier Children. A Better World.

Don't miss out on the opportunity to work alongside the world's best in paediatric healthcare.

The Research Associate possesses and applies highly advanced scientific knowledge of innovative research principles, theories and concepts. This Research Associate position will be in a fundamental research group within the Molecular Medicine program to work on early stage drug discovery projects that entail the design, screening, and structural characterization of novel small molecule and/or biologic therapeutic candidates. Applications will span multiple disease areas including infectious disease, cancer, and neurobiology. We are seeking an individual with a passion for science who is eager to learn, has strong initiative, and who will work well within a multidisciplinary team. The Research Associate will be responsible for leading a variety of projects and will report directly to the Principle Investigator.

Here's What You'll Get To Do

• Develop and implement cutting-edge drug discovery methods
• Develop primary and secondary assays against a variety of targets
• Design and carry out small molecule or protein-based biologic screens
• Use biophysical methods to characterize hit-target interactions
• Purification of targets and co-structure determination with ligands
• Write up of project reports, manuscripts, and grant applications
• Present results at relevant scientific meetings and conferences
• Interactions with local, national and international collaborators
• Maintain complete records of experimental data and procedures
• Instruction and/or co-supervision of trainees and other staff

Here's What You'll Need

• Proven track record in small molecule screen design and implementation
• Direct experience in protein purification, biochemical, and biophysical methods
• Deep expertise in structural biology, particularly X-ray crystallography and NMR
• Familiarity with bioinformatics workflows and software packages
• Ability to work both independently and cooperatively within a team
• Ability to quickly adapt and multitask on changing work flows and projects
• Ability to deliver on project goals in a timely manner
• Ability to seek and assimilate new knowledge for formulation of new projects
• Strong oral and written communication skills
• A commitment to understanding and aiding in the pursuit of equity, diversity and inclusion objectives

Education Required

• PhD in drug discovery, biophysics, or structural biology
• Postdoctoral experience in drug discovery, biophysics, or structural biology

Employment Type: Full-Time 1 Year Contract

SickKids is committed to championing equity, diversity and inclusion in all that we do, fostering an intentionally inclusive and culturally safe environment that reflects the diversity of the patients, families and communities we serve. Learn more about workplace inclusion.

If you require accommodation during the application process, please reach out to our aSKHR team. SickKids can provide access and inclusion supports to eligible candidates to support their full engagement during the interview and selection process as well as to ensure candidates are able to perform their duties once successfully hired. If you are invited for an interview and require accommodation, please let us know at the time of your invitation to interview. Information received related to access, inclusion or accommodation will be addressed confidentially.

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