Reference No. R2812620
Position Title: Upstream Scientist Vaccines
Department: DS Unit 1 NA
Duration: Fixed Term Contract, 12 months
Location: Toronto, ON
About the Job
We deliver 4.3 billion healthcare solutions to people every year, thanks to the flawless planning and meticulous eye for detail of our Manufacturing & Supply teams. With your talent and ambition, we can do even more to protect people from infectious diseases and bring hope to patients and their families.
As Scientist, responsible for specific scientific, technical and compliance-related aspects of assigned projects to ensure that objectives are met. Plan and supervise the execution of development activities to ensure scientific excellence, adherence to advanced technical standards and compliance with GxP status of work. Fulfill the roles and responsibilities of a Scientist as defined by the Head of VDSD and Unit head.
We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing Progress to make a real impact on millions of patients around the world.
Main responsibilities:
Scientific: Designs platform's experimental plan in support of projects. Prepares process development reports, scientific publications and external presentations.
Contribution to Projects: Working group member for responsible projects.
Responsibilities: Lead DKMs for responsible projects.
Strategy and Impact: Influence and implement departmental and company strategies within VCDS
Influence: Interact throughout VCDS
General
As Scientist, L2-1, responsible for specific scientific, technical and compliance aspects of assigned project to ensure that objectives are met. Plan and supervise execution of process and product development activities (develop, improve, scale-up processes, and provide material and documentation supporting vaccine production for pre-clinical and clinical trials) within the Platform for the project to ensure scientific and technical excellence.
Supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks. Ensure compliance of staff with GxP and other quality and documentation requirements, such as preparation of SOPs, BPRs and validation reports. Provide guidance on data input, standardized formats, database creation and management, and implementation of corporate standards.
To ensure good scientific and technical leadership within VDSD, keep abreast of the current developments in relevant scientific and technical disciplines and ensure current developments are implemented when appropriate.
Prepare internal and external presentations, research manuscripts and review articles as required.
Share information and harmonize development within VDSD, and other departments such as Research, Manufacturing Technology, Industrial Operations, Quality Operations, Regulatory Affairs, Clinical/Medical as necessary. Ensure good teamwork and provide high quality deliverables, such as Technical reports, development reports within agreed timeframes. Support regulatory submission by participating in preparation of regulatory submission documents (CTA, IND, CTD).
In depth knowledge of experimental work and data analysis. Working knowledge of computer skills, scientific writing and presentations, supervisory/management/people development, communication skills, innovative thinking, and a familiarity with strategic planning, balanced judgment, risk analysis and budget process is required.
Works with the policies, procedures and regulations as required by the Company and under Occupational Health and Safety Act. Ensure compliance with employment and health and safety legislation and ensure that employees follow the policies, procedures and regulations in the work areas.
Platform Specific
Genetic engineering of microbial and cells and viruses for vaccine supply using molecular biology approaches, followed by preparation of pre-master seeds, cell lines and virus stocks and their characterization.
Development of media and nutrient feeds for the cultivation of microbes, animal cells and viruses for vaccine candidate supply. Development of process for GMP manufacturing of master and working cell bank and virus seeds. Development of scalable bioreactor process for GMP manufacturing of vaccine candidates including the selection of operating mode (batch, fed batch, continuous, biphasic, etc) and conditions for production scales of up to 200 L. Selection of scalable primary recovery approaches for bioreactor harvest concentration, cell disruption, and product recovery using combinations of filtration, centrifugation, homogenization, sonication, and chemical treatments.
Use of analytical methods for measuring cell densities, culture medium analysis, protein analysis, immunological detection of proteins (ELISA, Western blotting, etc), HPLC, virus titration by CCID or plaque assay, flow cytometry, and PCR.
Support for GMP manufacturing including process technology transfer, equipment selection and validation, process flows, vendor and raw materials selection, aseptic processing, and sterilization.
Application of biochemical engineering principles including mass and heat transfer, fluid dynamics, process control, process simulation and modelling, and equipment design. Use of advanced computer software to support bioreactor process control and data acquisition, DOE, process modelling and simulations, computational fluid dynamics, and experimental data analysis.
About You
Requirements
Education/experience
Recommended PhD (Molecular Biology, Biochemistry, Microbiology, Virology, Biochemical Engineering)
Recommended 1+ years’ experience with a PhD or 4+ years’ experience with an MSc in vaccine development or relevant field.
Depending on development platform, in-depth knowledge in genetic engineering, upstream processes, downstream processes, formulation and stability.
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs
This position is for a current vacant role that we are actively hiring for.
Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to attract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
Les employés peuvent être admissibles à participer aux programmes d'avantages sociaux de l'entreprise. Des informations supplémentaires sur les avantages sociaux peuvent être trouvées ici.