Company Description
Chronological ageing is a biological process that results in accumulated cellular damage, ultimately driving the onset of metabolic disfunction. We aim to develop new therapeutic approaches to these ageing-associated diseases, by targeting metabolism in cancer stem cells (CSCs) and senescent fibroblasts. More specifically, we will screen a series of chemical libraries containing FDA-approved drugs, natural products, and novel chemical entities, to identify compounds that can effectively age-associated metabolic features. Through this screening and validation approach, we will identify compounds that preferentially kill CSCs and senescent fibroblasts, using established cell lines.
This position will involve the screening and discovery of drugs that target the metabolic phenotype of senescent cells and cancer stem cells, across multiple cancer types.
Job Description
The purpose of this role is to support Lunella Biotech’s mission in the discovery of anti-ageing and anti-cancer therapeutics.
Responsibilities
- To engage with Lunella’s mission to fight ageing and cancer by developing novel therapeutic strategies
- To develop research objectives in connection with the project outlined above and in agreement with the laboratory heads
- To perform experiments in the laboratory to test hypotheses regarding ageing and cancer
- To write up draft reports for manuscript publication and patent evaluation
- To present data as required, during lab meetings and conferences
- To assist in the supervision of graduate students and staff
- To collaborate with members within and outside of the laboratory
- To comply with Health and Safety regulations
- To promote equality and diversity and sustain an inclusive and supportive work environment
- This role detail is a guide to the work you will initially be required to undertake. It may be changed from time to time to meet changing circumstances
Qualifications
- Completed PhD in related biological/pharmaceutical sciences
- Publication record in peer-reviewed journals
Background & Experience
Essential criteria
- Experience in flow cytometry/FACS analysis
- Experience and a track record in working with and developing a variety of techniques
- Experience in the generation of stable cell lines using transfection methods
- Experience in aseptic techniques for mammalian cell culture
- Experience in recording, analyzing and interpreting data
- Experience in confocal or fluorescent microscopy
Desirable criteria
- Experience in assays measuring metabolic parameters of cellular models
- Experience in cell migration and invasion assays
- Experience in the co-culture of multiple cell types
- Experience in proteomics
- Experience in drug screening
Skills & Competencies
Essential criteria
- Ability to work independently within an agreed framework
- Excellent communication skills on paper and verbally, including good IT skills
- Ability to work as part of a team
- Proven ability to follow directions
- Ability and willingness to learn new analytical methods and skills
Desirable criteria
- Good organizational skills
- To provide guidance to other staff on own specialist area
- Experience in writing papers and scientific reports
Additional Information
As an equal opportunity employer, Lunella Biotech Inc. is committed to achieving a skilled and diversified workforce that reflects the diversity of the Canadian population. We encourage applications from women, visible minorities, people with disabilities and Aboriginal people.
